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</ul> </div> </div> </div> </header> <div class="top-bar"> <div class="container"> <header class="page-header"> <h1 class="page-title">preclinical</h1> </header><!-- .page-header --> <div class="breadcrumb-wrapper"> <div id="crumbs" itemscope itemtype="http://schema.org/BreadcrumbList"> <span itemprop="itemListElement" itemscope itemtype="http://schema.org/ListItem"> <a itemprop="item" href="https://ddblog.labcorp.com"><span itemprop="name">Home</span></a> <meta itemprop="position" content="1" /> <span class="separator">/</span> </span><span class="current" itemprop="itemListElement" itemscope itemtype="http://schema.org/ListItem"><a itemprop="item" href="https://ddblog.labcorp.com/tag/preclinical/"><span itemprop="name">preclinical</span></a><meta itemprop="position" content="2" /></span></div></div><!-- .breadcrumb-wrapper --> </div> </div> <div class="container main-content"> <div id="content" class="site-content"> <div class="row"> <div id="primary" class="content-area"> <main id="main" class="site-main"> <div class="row"> <article id="post-8989" class="post-8989 post type-post status-publish format-standard has-post-thumbnail hentry category-preclinical-nonclinical tag-anti-idiotype tag-antibodies tag-cro tag-drug-development tag-polyclonal tag-preclinical latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2022/08/generation-of-polyclonal-anti-idiotype-antibodies/" class="post-thumbnail"><img width="450" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2022/07/lab080817_p01-171_BE-600x400-d9c3bb2-450x300.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="Labcorp scientist working in a lab" srcset="https://ddblog.labcorp.com/wp-content/uploads/2022/07/lab080817_p01-171_BE-600x400-d9c3bb2-450x300.jpg 450w, https://ddblog.labcorp.com/wp-content/uploads/2022/07/lab080817_p01-171_BE-600x400-d9c3bb2-300x200.jpg 300w, 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itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/covance/">Labcorp</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2022/08/generation-of-polyclonal-anti-idiotype-antibodies/" rel="bookmark"><time class="entry-date published updated" datetime="2022-08-01T09:26:47-04:00" itemprop="dateModified">Monday, August 1, 2022</time><time class="updated" datetime="2022-08-01T09:26:46-04:00" itemprop="datePublished">Monday, August 1, 2022</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>An idiotype is a unique antigen-binding site in an antibody and is made up of several epitopes in the variable region. Antibodies raised against the idiotype of a given antibody are called anti-idiotypic antibodies or commonly anti-Ids. These anti-Ids are highly specialized reagents that are produced against human monoclonal antibody … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-8989 --> <article id="post-4974" class="post-4974 post type-post status-publish format-standard has-post-thumbnail hentry category-drug-development category-preclinical-nonclinical tag-preclinical latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2019/04/treating-age-related-macular-degeneration-amd-with-a-novel-stem-cell-therapy/" class="post-thumbnail"><img width="450" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2015/08/Covance-Workers-In-Lab-Blog.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="" srcset="https://ddblog.labcorp.com/wp-content/uploads/2015/08/Covance-Workers-In-Lab-Blog.jpg 1500w, 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href="https://ddblog.labcorp.com/2019/04/treating-age-related-macular-degeneration-amd-with-a-novel-stem-cell-therapy/" rel="bookmark">Treating age-related macular degeneration (AMD) with a novel stem cell therapy</a></h2><div class="entry-meta"><span class="byline" itemprop="author" itemscope itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/covance/">Labcorp</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2019/04/treating-age-related-macular-degeneration-amd-with-a-novel-stem-cell-therapy/" rel="bookmark"><time class="entry-date published updated" datetime="2021-06-07T14:10:48-04:00" itemprop="dateModified">Monday, June 7, 2021</time><time class="updated" datetime="2019-04-10T14:32:10-04:00" itemprop="datePublished">Wednesday, April 10, 2019</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>About the Audacious Goals Initiative & the National Eye Institute (NEI) The Audacious Goals Initiative (AGI) for regenerative medicine is a program run by the National Eye Institute (NEI), aimed at finding new therapies for eye diseases that remain difficult to treat. Age-related macular degeneration is the leading cause of vision loss in the … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-4974 --> <article id="post-4994" class="post-4994 post type-post status-publish format-standard has-post-thumbnail hentry category-clinical-development category-device category-pilot category-pivotal tag-brexit tag-clinical tag-medical-device tag-preclinical latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2019/02/how-a-no-deal-brexit-might-affect-medical-device-development-legal-consequences-and-risk-mitigation-strategies/" class="post-thumbnail"><img width="450" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2019/07/16.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="Image of Flag of Great Britain Overlapped with United Nations Flag" 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href="https://ddblog.labcorp.com/2019/02/how-a-no-deal-brexit-might-affect-medical-device-development-legal-consequences-and-risk-mitigation-strategies/" rel="bookmark"><time class="entry-date published updated" datetime="2021-06-07T14:19:36-04:00" itemprop="dateModified">Monday, June 7, 2021</time><time class="updated" datetime="2019-02-21T13:46:44-05:00" itemprop="datePublished">Thursday, February 21, 2019</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>How could a no-deal Brexit affect my medical device lifecycle? Considerable uncertainty surrounds Britain’s imminent exit from the EU, and it is possible that there could be a “no-deal Brexit” scenario. The full implications are still unclear, however it is a stressful time for UK manufacturers and sponsors of medical … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-4994 --> <article id="post-2670" class="post-2670 post type-post status-publish format-standard has-post-thumbnail hentry category-clinical-development category-drug-development category-nash category-preclinical-nonclinical tag-nafld tag-nash tag-preclinical latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" class="post-thumbnail"><img width="450" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="Pre-Clinical Issues in NASH Development Covance Blog" srcset="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH.jpg 1500w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-300x200.jpg 300w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-768x512.jpg 768w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-1024x683.jpg 1024w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-450x300.jpg 450w" sizes="(max-width: 450px) 100vw, 450px" data-attachment-id="2672" data-permalink="https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/covance-pre-clinical-nash/" data-orig-file="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH.jpg" data-orig-size="1500,1000" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Covance Pre Clinical NASH" data-image-description="<p>Pre-Clinical Issues in NASH Development Covance Blog</p> " data-medium-file="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-300x200.jpg" data-large-file="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-1024x683.jpg" /></a> <div class="text-holder"> <header class="entry-header"> <div class="top"> <div class="share"> <i class="fa fa-share-alt"></i>Share <div class="social-networks"> <ul> <li><a href="https://www.linkedin.com/shareArticle?mini=true&url=https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/&title=How%20to%20Navigate%20Pre-Clinical%20Issues%20in%20NASH%20Development" rel="nofollow" target="_blank"><i class="fa fa-linkedin" aria-hidden="true"></i></a></li><li><a href="https://twitter.com/home?status=How%20to%20Navigate%20Pre-Clinical%20Issues%20in%20NASH%20Development https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" rel="nofollow" target="_blank"><i class="fa fa-twitter" aria-hidden="true"></i></a></li><li><a href="https://www.facebook.com/sharer/sharer.php?u=https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" rel="nofollow" target="_blank"><i class="fa fa-facebook" aria-hidden="true"></i></a></li><li><a href="/cdn-cgi/l/email-protection#d7e884a2b5bdb2b4a3ea9fb8a0f2e5e7a3b8f2e5e799b6a1beb0b6a3b2f2e5e787a5b2fa94bbbeb9beb4b6bbf2e5e79ea4a4a2b2a4f2e5e7beb9f2e5e79996849ff2e5e793b2a1b2bbb8a7bab2b9a3f1f4e7e4efec95b8b3aeeabfa3a3a7a4edf8f8b3b3b5bbb8b0f9bbb6b5b4b8a5a7f9b4b8baf8e5e7e6e1f8e7e3f8b9b6a1beb0b6a3b2faa7a5b2fab4bbbeb9beb4b6bbfabea4a4a2b2a4fab9b6a4bffab3b2a1b2bbb8a7bab2b9a3f8" rel="nofollow" target="_blank"><i class="fa fa-envelope" aria-hidden="true"></i></a></li> </ul> </div> </div> </div><h2 class="entry-title" itemprop="headline"><a href="https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" rel="bookmark">How to Navigate Pre-Clinical Issues in NASH Development</a></h2><div class="entry-meta"><span class="byline" itemprop="author" itemscope itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/gould/">Kenneth E. Gould, PhD and Subba Rao Chintalacharuvu, PhD</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" rel="bookmark"><time class="entry-date published updated" datetime="2021-05-19T12:45:27-04:00" itemprop="dateModified">Wednesday, May 19, 2021</time><time class="updated" datetime="2016-04-12T13:31:21-04:00" itemprop="datePublished">Tuesday, April 12, 2016</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>The pre-clinical phase of development for non-alcoholic steatohepatitis (NASH) drugs faces many challenges. Biopharmaceutical companies have several options for rodent models, but they must weigh factors such as customization versus speed before deciding on the best approach. Some of the challenges include: Diet: There is no prevailing wisdom in the … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-2670 --> </div> <div class="pagination"></div> </main><!-- #main --> </div><!-- #primary --> </div><!-- .row/not-found --> </div><!-- #content --> </div><!-- .container/.main-content --> <footer id="colophon" class="site-footer" itemscope itemtype="http://schema.org/WPFooter"> <div class="site-info"> <div class="container"> <span class="copyright">Copyright © 2022 Labcorp All rights reserved.</span> </div> </div> </footer><!-- #colophon --> <button aria-label="go to top" id="blossom-top"> <span><i class="fa fa-angle-up"></i>TOP</span> </button> </div><!-- #page --> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/all.min.js?ver=5.6.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/v4-shims.min.js?ver=5.6.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/sticky-kit.min.js?ver=1.1.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/owl.carousel.min.js?ver=2.2.1'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/owl.carousel.aria.min.js?ver=2.0.0'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/jquery.matchHeight.min.js?ver=0.7.2'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/wow.min.js?ver=1.1.3'></script> <script type='text/javascript'> /* <![CDATA[ */ var bfp_data = {"lightbox":"","auto":"","loop":"","speed":"3000","animation":"fadeOut","child":"default","sticky":"","sticky_widget":"","header":"eight","url":"https:\/\/ddblog.labcorp.com\/wp-admin\/admin-ajax.php","rtl":""}; /* ]]> */ </script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/custom.min.js?ver=2.3.3'></script> <script type='text/javascript'> /* <![CDATA[ */ var bfp_ajax = {"url":"https:\/\/ddblog.labcorp.com\/wp-admin\/admin-ajax.php","startPage":"1","maxPages":"1","nextLink":null,"autoLoad":"load_more","loadmore":"Load More Posts","loading":"Loading...","nomore":"No More Post","layouts":"two-col-right","plugin_url":"https:\/\/ddblog.labcorp.com\/wp-content\/plugins"}; /* ]]> */ </script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/ajax.min.js?ver=2.3.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-includes/js/wp-embed.min.js?ver=5.4'></script> <script type="text/javascript"> if(typeof _satellite !== "undefined"){ _satellite.pageBottom(); } </script> </body> </html>