</ iframe></noscript> <!-- End Google Tag Manager (noscript) --> <div id="page" class="site"><a aria-label="skip to content" class="skip-link" href="#content">Skip to Content</a> <header class="site-header header-layout-three header-layout-seven header-layout-eight" itemscope itemtype="http://schema.org/WPHeader"> <div class="header-holder"> <div class="header-m" style="background-image:url(https://ddblog.labcorp.com/wp-content/uploads/2021/07/blog-header-1.png)"> <div class="container"> <div class="site-branding" itemscope itemtype="http://schema.org/Organization"> <p class="site-title" itemprop="name"><a href="https://ddblog.labcorp.com/" rel="home" itemprop="url">Insights From Our Labs to Yours</a></p> <p class="site-description" itemprop="description">Labcorp Drug Development Blog</p> </div> </div> </div> </div> <div class="sticky-holder"></div> <div class="header-b"> <div class="container"> <button aria-label="primary menu toggle" id="primary-toggle-button"><i class="fa fa-bars"></i>Navigation</button> <nav id="site-navigation" class="main-navigation" itemscope itemtype="http://schema.org/SiteNavigationElement"> <div class="menu-main-container"><ul id="primary-menu" class="menu"><li id="menu-item-6077" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-home menu-item-6077"><a href="https://ddblog.labcorp.com">Home</a></li> <li id="menu-item-5821" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-has-children menu-item-5821"><a href="https://ddblog.labcorp.com/industry/">Industry</a> <ul class="sub-menu"> <li id="menu-item-5824" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5824"><a href="https://ddblog.labcorp.com/industry/device/">Device</a></li> <li id="menu-item-5825" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5825"><a href="https://ddblog.labcorp.com/industry/drug-development/">Drug</a></li> <li id="menu-item-5822" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5822"><a href="https://ddblog.labcorp.com/industry/chemical/">Chemical</a></li> <li id="menu-item-5823" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5823"><a href="https://ddblog.labcorp.com/industry/crop/">Crop</a></li> </ul> </li> <li id="menu-item-5828" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-has-children menu-item-5828"><a href="https://ddblog.labcorp.com/phase/">Phase</a> <ul class="sub-menu"> <li id="menu-item-5829" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5829"><a href="https://ddblog.labcorp.com/phase/discovery/">Discovery</a></li> <li id="menu-item-5835" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5835"><a href="https://ddblog.labcorp.com/phase/preclinical-nonclinical/">Preclinical/Nonclinical</a></li> <li id="menu-item-5831" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5831"><a href="https://ddblog.labcorp.com/phase/phase-i-iia/">Phase I-IIa</a></li> <li id="menu-item-5832" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5832"><a href="https://ddblog.labcorp.com/phase/phase-iib-iii/">Phase IIb-III</a></li> <li id="menu-item-5833" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5833"><a href="https://ddblog.labcorp.com/phase/pilot/">Pilot</a></li> <li id="menu-item-5834" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5834"><a href="https://ddblog.labcorp.com/phase/pivotal/">Pivotal</a></li> <li id="menu-item-5830" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5830"><a href="https://ddblog.labcorp.com/phase/formulation-packaging/">Formulation, Packaging, etc.</a></li> </ul> </li> <li id="menu-item-5836" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-has-children menu-item-5836"><a href="https://ddblog.labcorp.com/molecule-type/">Molecule Type</a> <ul class="sub-menu"> <li id="menu-item-5837" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5837"><a href="https://ddblog.labcorp.com/molecule-type/biologics/">Biologics</a></li> <li id="menu-item-5841" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5841"><a href="https://ddblog.labcorp.com/molecule-type/small-molecules/">Small Molecules</a></li> <li id="menu-item-5839" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5839"><a href="https://ddblog.labcorp.com/molecule-type/biosimilars/">Biosimilars</a></li> <li id="menu-item-5838" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5838"><a href="https://ddblog.labcorp.com/molecule-type/biomarkers/">Biomarkers</a></li> <li id="menu-item-5840" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5840"><a href="https://ddblog.labcorp.com/molecule-type/cell-gene-therapies/">Cell/Gene Therapies</a></li> </ul> </li> <li id="menu-item-5844" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-has-children menu-item-5844"><a href="https://ddblog.labcorp.com/data-informatics/">Data/Informatics</a> <ul class="sub-menu"> <li id="menu-item-5842" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5842"><a href="https://ddblog.labcorp.com/data-informatics/send/">SEND</a></li> <li id="menu-item-5845" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5845"><a href="https://ddblog.labcorp.com/data-informatics/modeling/">Modeling</a></li> <li id="menu-item-5846" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5846"><a href="https://ddblog.labcorp.com/data-informatics/patient-recruitment/">Patient Recruitment</a></li> <li id="menu-item-5843" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5843"><a href="https://ddblog.labcorp.com/data-informatics/xcellerate/">Xcellerate</a></li> </ul> </li> <li id="menu-item-5827" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-has-children menu-item-5827"><a href="https://ddblog.labcorp.com/about-covance/">About Us</a> <ul class="sub-menu"> <li id="menu-item-5704" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-5704"><a href="https://ddblog.labcorp.com/about-covance/careers-and-culture/">Careers and Culture</a></li> <li id="menu-item-5792" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5792"><a href="http://response.covance.com/contact-us?elqCampaignId=399&cid=Web_Clk_CVD_blog_megamenunav_0615_399">Contact Us</a></li> <li id="menu-item-5791" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5791"><a href="https://drugdevelopment.labcorp.com">Labcorp Drug Development</a></li> </ul> </li> </ul></div> </nav><!-- #site-navigation --> <div class="right"> <div class="tools"> <div class="form-section"> <button aria-label="search form toggle" id="btn-search"><i class="fa fa-search"></i></button> <div class="form-holder"> <form role="search" method="get" class="search-form" action="https://ddblog.labcorp.com/"> <label> <span class="screen-reader-text">Search for:</span> <input type="search" class="search-field" placeholder="Search …" value="" name="s" /> </label> <input type="submit" class="search-submit" value="Search" /> </form> </div> </div> </div> <ul class="social-networks"> <li><a href="https://www.linkedin.com/company/labcorpdrugdevelopment" target="_blank" rel="nofollow"><i class="fab fa-linkedin"></i></a></li> <li><a href="https://twitter.com/LabcorpDrugDev" target="_blank" rel="nofollow"><i class="fab fa-twitter-square"></i></a></li> <li><a href="https://www.facebook.com/LabcorpDrugDevelopment" target="_blank" rel="nofollow"><i class="fab fa-facebook"></i></a></li> </ul> </div> </div> </div> </header> <div class="top-bar"> <div class="container"> <header class="page-header"> <h1 class="page-title">NASH</h1> </header><!-- .page-header --> <div class="breadcrumb-wrapper"> <div id="crumbs" itemscope itemtype="http://schema.org/BreadcrumbList"> <span itemprop="itemListElement" itemscope itemtype="http://schema.org/ListItem"> <a itemprop="item" href="https://ddblog.labcorp.com"><span itemprop="name">Home</span></a> <meta itemprop="position" content="1" /> <span class="separator">/</span> </span> <span itemprop="itemListElement" itemscope itemtype="http://schema.org/ListItem"><a itemprop="item" href="https://ddblog.labcorp.com/therapeutic-area/"><span itemprop="name">Therapeutic Area </span></a><meta itemprop="position" content="2" /><span class="separator">/</span></span> <span class="current" itemprop="itemListElement" itemscope itemtype="http://schema.org/ListItem"> <a itemprop="item" href="https://ddblog.labcorp.com/therapeutic-area/nash/"><span itemprop="name">NASH</span></a><meta itemprop="position" content="3" /> </span></div></div><!-- .breadcrumb-wrapper --> </div> </div> <div class="container main-content"> <div id="content" class="site-content"> <div class="row"> <div id="primary" class="content-area"> <main id="main" class="site-main"> <div class="row"> <article id="post-6442" class="post-6442 post type-post status-publish format-standard has-post-thumbnail hentry category-drug-development category-nash category-preclinical-nonclinical tag-biomarkers tag-nafld tag-nash tag-precision-medicine latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2020/04/biomarkers-diagnostics-growing-influence-on-drug-development-for-nafld-nash/" class="post-thumbnail"><img width="450" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2020/04/Covance-NASH-Liver-450x300.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="" data-attachment-id="6444" data-permalink="https://ddblog.labcorp.com/2020/04/biomarkers-diagnostics-growing-influence-on-drug-development-for-nafld-nash/covance-nash-liver/" data-orig-file="https://ddblog.labcorp.com/wp-content/uploads/2020/04/Covance-NASH-Liver.jpg" data-orig-size="726,1000" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Covance NASH Liver" data-image-description="" data-medium-file="https://ddblog.labcorp.com/wp-content/uploads/2020/04/Covance-NASH-Liver-218x300.jpg" data-large-file="https://ddblog.labcorp.com/wp-content/uploads/2020/04/Covance-NASH-Liver.jpg" /></a> <div class="text-holder"> <header class="entry-header"> <div class="top"> <div class="share"> <i class="fa fa-share-alt"></i>Share <div class="social-networks"> <ul> <li><a href="https://www.linkedin.com/shareArticle?mini=true&url=https://ddblog.labcorp.com/2020/04/biomarkers-diagnostics-growing-influence-on-drug-development-for-nafld-nash/&title=Biomarkers%20&%20Diagnostics:%20growing%20influence%20on%20drug%20development%20for%20NAFLD/NASH" rel="nofollow" target="_blank"><i class="fa fa-linkedin" aria-hidden="true"></i></a></li><li><a href="https://twitter.com/home?status=Biomarkers%20&%20Diagnostics:%20growing%20influence%20on%20drug%20development%20for%20NAFLD/NASH https://ddblog.labcorp.com/2020/04/biomarkers-diagnostics-growing-influence-on-drug-development-for-nafld-nash/" rel="nofollow" target="_blank"><i class="fa fa-twitter" aria-hidden="true"></i></a></li><li><a href="https://www.facebook.com/sharer/sharer.php?u=https://ddblog.labcorp.com/2020/04/biomarkers-diagnostics-growing-influence-on-drug-development-for-nafld-nash/" rel="nofollow" target="_blank"><i class="fa fa-facebook" aria-hidden="true"></i></a></li><li><a href="/cdn-cgi/l/email-protection#80bfd3f5e2eae5e3f4bdc2e9efede1f2ebe5f2f3a5b2b0a6a3b0b3b8bba5b2b0c4e9e1e7eeeff3f4e9e3f3baa5b2b0e7f2eff7e9eee7a5b2b0e9eee6ecf5e5eee3e5a5b2b0efeea5b2b0e4f2f5e7a5b2b0e4e5f6e5eceff0ede5eef4a5b2b0e6eff2a5b2b0cec1c6ccc4afcec1d3c8a6a3b0b3b8bbc2efe4f9bde8f4f4f0f3baafafe4e4e2ecefe7aeece1e2e3eff2f0aee3efedafb2b0b2b0afb0b4afe2e9efede1f2ebe5f2f3ade4e9e1e7eeeff3f4e9e3f3ade7f2eff7e9eee7ade9eee6ecf5e5eee3e5adefeeade4f2f5e7ade4e5f6e5eceff0ede5eef4ade6eff2adeee1e6ece4adeee1f3e8af" rel="nofollow" target="_blank"><i class="fa fa-envelope" aria-hidden="true"></i></a></li> </ul> </div> </div> </div><h2 class="entry-title" itemprop="headline"><a href="https://ddblog.labcorp.com/2020/04/biomarkers-diagnostics-growing-influence-on-drug-development-for-nafld-nash/" rel="bookmark">Biomarkers & Diagnostics: growing influence on drug development for NAFLD/NASH</a></h2><div class="entry-meta"><span class="byline" itemprop="author" itemscope itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/covance/">Labcorp Drug Development</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2020/04/biomarkers-diagnostics-growing-influence-on-drug-development-for-nafld-nash/" rel="bookmark"><time class="entry-date published updated" datetime="2021-06-07T16:01:31-04:00" itemprop="dateModified">Monday, June 7, 2021</time><time class="updated" datetime="2020-04-30T19:50:20-04:00" itemprop="datePublished">Thursday, April 30, 2020</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>Biomarkers and diagnostics are playing an ever-increasing role in drug development. Personalized medicines, defined as drug therapies used alongside specific diagnostic tests, topped 40% of all FDA approvals in 2018. Across biopharma, drug developers increased their utilization of selection biomarkers, significantly improving the probability of success for their clinical programs.1, … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-6442 --> <article id="post-3559" class="post-3559 post type-post status-publish format-standard has-post-thumbnail hentry category-clinical-development category-drug-development category-nash category-phase-iib-iii tag-cvd tag-nafld tag-nash tag-nonalcoholic-fatty-liver-disease tag-nonalcoholic-steatohepatitis latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2018/01/challenges-in-the-diagnosis-of-nafld-nash-and-comorbidities-in-the-pediatric-population/" class="post-thumbnail"><img width="300" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2018/01/NASH-Liver.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="NASH NAFLD Blog" srcset="https://ddblog.labcorp.com/wp-content/uploads/2018/01/NASH-Liver.jpg 335w, https://ddblog.labcorp.com/wp-content/uploads/2018/01/NASH-Liver-150x150.jpg 150w, https://ddblog.labcorp.com/wp-content/uploads/2018/01/NASH-Liver-300x300.jpg 300w" sizes="(max-width: 300px) 100vw, 300px" data-attachment-id="3562" data-permalink="https://ddblog.labcorp.com/2018/01/challenges-in-the-diagnosis-of-nafld-nash-and-comorbidities-in-the-pediatric-population/nash-liver/" data-orig-file="https://ddblog.labcorp.com/wp-content/uploads/2018/01/NASH-Liver.jpg" data-orig-size="335,335" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="NASH-Liver" data-image-description="<p>NASH NAFLD Blog</p> " data-medium-file="https://ddblog.labcorp.com/wp-content/uploads/2018/01/NASH-Liver-300x300.jpg" data-large-file="https://ddblog.labcorp.com/wp-content/uploads/2018/01/NASH-Liver.jpg" /></a> <div class="text-holder"> <header class="entry-header"> <div class="top"> <div class="share"> <i class="fa fa-share-alt"></i>Share <div class="social-networks"> <ul> <li><a href="https://www.linkedin.com/shareArticle?mini=true&url=https://ddblog.labcorp.com/2018/01/challenges-in-the-diagnosis-of-nafld-nash-and-comorbidities-in-the-pediatric-population/&title=Challenges%20in%20the%20Diagnosis%20of%20NAFLD,%20NASH%20and%20Comorbidities%20in%20the%20Pediatric%20Population" rel="nofollow" target="_blank"><i class="fa fa-linkedin" aria-hidden="true"></i></a></li><li><a href="https://twitter.com/home?status=Challenges%20in%20the%20Diagnosis%20of%20NAFLD,%20NASH%20and%20Comorbidities%20in%20the%20Pediatric%20Population https://ddblog.labcorp.com/2018/01/challenges-in-the-diagnosis-of-nafld-nash-and-comorbidities-in-the-pediatric-population/" rel="nofollow" target="_blank"><i class="fa fa-twitter" aria-hidden="true"></i></a></li><li><a href="https://www.facebook.com/sharer/sharer.php?u=https://ddblog.labcorp.com/2018/01/challenges-in-the-diagnosis-of-nafld-nash-and-comorbidities-in-the-pediatric-population/" rel="nofollow" target="_blank"><i class="fa fa-facebook" aria-hidden="true"></i></a></li><li><a href="/cdn-cgi/l/email-protection#8db2def8efe7e8eef9b0cee5ece1e1e8e3eae8fea8bfbde4e3a8bfbdf9e5e8a8bfbdc9e4eceae3e2fee4fea8bfbde2eba8bfbdc3cccbc1c9a1a8bfbdc3ccdec5a8bfbdece3e9a8bfbdcee2e0e2ffefe4e9e4f9e4e8fea8bfbde4e3a8bfbdf9e5e8a8bfbddde8e9e4ecf9ffe4eea8bfbddde2fdf8e1ecf9e4e2e3abaebdbeb5b6cfe2e9f4b0e5f9f9fdfeb7a2a2e9e9efe1e2eaa3e1ecefeee2fffda3eee2e0a2bfbdbcb5a2bdbca2eee5ece1e1e8e3eae8fea0e4e3a0f9e5e8a0e9e4eceae3e2fee4fea0e2eba0e3ecebe1e9a0e3ecfee5a0ece3e9a0eee2e0e2ffefe4e9e4f9e4e8fea0e4e3a0f9e5e8a0fde8e9e4ecf9ffe4eea0fde2fdf8e1ecf9e4e2e3a2" rel="nofollow" target="_blank"><i class="fa fa-envelope" aria-hidden="true"></i></a></li> </ul> </div> </div> </div><h2 class="entry-title" itemprop="headline"><a href="https://ddblog.labcorp.com/2018/01/challenges-in-the-diagnosis-of-nafld-nash-and-comorbidities-in-the-pediatric-population/" rel="bookmark">Challenges in the Diagnosis of NAFLD, NASH and Comorbidities in the Pediatric Population</a></h2><div class="entry-meta"><span class="byline" itemprop="author" itemscope itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/margeryaconnellyphdmba/">Margery A. Connelly, PhD, MBA</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2018/01/challenges-in-the-diagnosis-of-nafld-nash-and-comorbidities-in-the-pediatric-population/" rel="bookmark"><time class="entry-date published updated" datetime="2020-02-17T16:07:11-05:00" itemprop="dateModified">Monday, February 17, 2020</time><time class="updated" datetime="2018-01-24T17:09:04-05:00" itemprop="datePublished">Wednesday, January 24, 2018</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>Nonalcoholic fatty liver disease (NAFLD) is the accumulation of fat or lipids in the liver in the absence of significant alcohol uptake or viral infection. Within NAFLD there is a spectrum of disease ranging from excess storage of fat in the liver (NAFL) to fat plus inflammation (called nonalcoholic steatohepatitis … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-3559 --> <article id="post-3298" class="post-3298 post type-post status-publish format-standard has-post-thumbnail hentry category-clinical-development category-drug-development category-nash category-phase-iib-iii tag-aging-and-comorbidities tag-inflammation tag-rheumatoid-arthritis latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2017/08/maximizing-real-world-data-impact-cvd-clinical-outcomes-ra/" class="post-thumbnail"><img width="206" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2017/08/Covance-RA-Blog-1.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="RA Patients" srcset="https://ddblog.labcorp.com/wp-content/uploads/2017/08/Covance-RA-Blog-1.jpg 349w, https://ddblog.labcorp.com/wp-content/uploads/2017/08/Covance-RA-Blog-1-206x300.jpg 206w" sizes="(max-width: 206px) 100vw, 206px" data-attachment-id="3336" data-permalink="https://ddblog.labcorp.com/2017/09/regional-availability-reimbursement-models-biologic-therapies-treat-ra-patients-moderate-severe-disease/covance-ra-blog-2/" data-orig-file="https://ddblog.labcorp.com/wp-content/uploads/2017/08/Covance-RA-Blog-1.jpg" data-orig-size="349,508" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Covance RA Blog" data-image-description="" data-medium-file="https://ddblog.labcorp.com/wp-content/uploads/2017/08/Covance-RA-Blog-1-206x300.jpg" data-large-file="https://ddblog.labcorp.com/wp-content/uploads/2017/08/Covance-RA-Blog-1.jpg" /></a> <div class="text-holder"> <header class="entry-header"> <div class="top"> <div class="share"> <i class="fa fa-share-alt"></i>Share <div class="social-networks"> <ul> <li><a href="https://www.linkedin.com/shareArticle?mini=true&url=https://ddblog.labcorp.com/2017/08/maximizing-real-world-data-impact-cvd-clinical-outcomes-ra/&title=Maximizing%20Real-World%20Data:%20Impact%20of%20Cardiovascular%20Disease%20on%20Clinical%20Outcomes%20in%20Rheumatoid%20Arthritis" rel="nofollow" target="_blank"><i class="fa fa-linkedin" aria-hidden="true"></i></a></li><li><a href="https://twitter.com/home?status=Maximizing%20Real-World%20Data:%20Impact%20of%20Cardiovascular%20Disease%20on%20Clinical%20Outcomes%20in%20Rheumatoid%20Arthritis https://ddblog.labcorp.com/2017/08/maximizing-real-world-data-impact-cvd-clinical-outcomes-ra/" rel="nofollow" target="_blank"><i class="fa fa-twitter" aria-hidden="true"></i></a></li><li><a href="https://www.facebook.com/sharer/sharer.php?u=https://ddblog.labcorp.com/2017/08/maximizing-real-world-data-impact-cvd-clinical-outcomes-ra/" rel="nofollow" target="_blank"><i class="fa fa-facebook" aria-hidden="true"></i></a></li><li><a href="/cdn-cgi/l/email-protection#e6d9b593848c838592dbab879e8f8b8f9c8f8881c3d4d6b483878acbb189948a82c3d4d6a2879287dcc3d4d6af8b96878592c3d4d68980c3d4d6a58794828f8990879585938a8794c3d4d6a28f9583879583c3d4d68988c3d4d6a58a8f888f85878ac3d4d6a9939285898b8395c3d4d68f88c3d4d6b48e83938b8792898f82c3d4d6a794928e948f928f95c0c5d6d5dedda489829fdb8e92929695dcc9c98282848a8981c88a878485899496c885898bc9d4d6d7d1c9d6dec98b879e8f8b8f9c8f8881cb9483878acb9189948a82cb82879287cb8f8b96878592cb859082cb858a8f888f85878acb89939285898b8395cb9487c9" rel="nofollow" target="_blank"><i class="fa fa-envelope" aria-hidden="true"></i></a></li> </ul> </div> </div> </div><h2 class="entry-title" itemprop="headline"><a href="https://ddblog.labcorp.com/2017/08/maximizing-real-world-data-impact-cvd-clinical-outcomes-ra/" rel="bookmark">Maximizing Real-World Data: Impact of Cardiovascular Disease on Clinical Outcomes in Rheumatoid Arthritis</a></h2><div class="entry-meta"><span class="byline" itemprop="author" itemscope itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/covance/">Labcorp Drug Development</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2017/08/maximizing-real-world-data-impact-cvd-clinical-outcomes-ra/" rel="bookmark"><time class="entry-date published updated" datetime="2021-05-19T13:49:39-04:00" itemprop="dateModified">Wednesday, May 19, 2021</time><time class="updated" datetime="2017-08-14T16:25:21-04:00" itemprop="datePublished">Monday, August 14, 2017</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>Current guidance on rheumatoid arthritis (RA) stresses the importance of considering comorbidity when assessing disease activity and making clinical decisions.1 Comorbidities commonly associated with RA include cardiovascular disease (CVD), lung disease and malignancy.2 The complex relationship between RA and CVD comorbidities The presence of CVD itself has been shown to … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-3298 --> <article id="post-2835" class="post-2835 post type-post status-publish format-standard has-post-thumbnail hentry category-drug-development category-nash category-phase-iib-iii tag-drug-development tag-nash tag-non-alcoholic-steatohepatitis latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2016/08/non-alcoholic-steatohepatitis/" class="post-thumbnail"><img width="300" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2016/07/Covance-NASH-Liver-Blog.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="The Development Landscape for Non-Alcoholic Steatohepatitis" srcset="https://ddblog.labcorp.com/wp-content/uploads/2016/07/Covance-NASH-Liver-Blog.jpg 6000w, https://ddblog.labcorp.com/wp-content/uploads/2016/07/Covance-NASH-Liver-Blog-150x150.jpg 150w, https://ddblog.labcorp.com/wp-content/uploads/2016/07/Covance-NASH-Liver-Blog-300x300.jpg 300w, https://ddblog.labcorp.com/wp-content/uploads/2016/07/Covance-NASH-Liver-Blog-768x768.jpg 768w, https://ddblog.labcorp.com/wp-content/uploads/2016/07/Covance-NASH-Liver-Blog-1024x1024.jpg 1024w" sizes="(max-width: 300px) 100vw, 300px" data-attachment-id="2838" data-permalink="https://ddblog.labcorp.com/2016/08/non-alcoholic-steatohepatitis/covance-nash-liver-blog/" data-orig-file="https://ddblog.labcorp.com/wp-content/uploads/2016/07/Covance-NASH-Liver-Blog.jpg" data-orig-size="6000,6000" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Covance NASH Liver Blog" data-image-description="<p>The Development Landscape for Non-Alcoholic Steatohepatitis Covance Scientific Blog</p> " data-medium-file="https://ddblog.labcorp.com/wp-content/uploads/2016/07/Covance-NASH-Liver-Blog-300x300.jpg" data-large-file="https://ddblog.labcorp.com/wp-content/uploads/2016/07/Covance-NASH-Liver-Blog-1024x1024.jpg" /></a> <div class="text-holder"> <header class="entry-header"> <div class="top"> <div class="share"> <i class="fa fa-share-alt"></i>Share <div class="social-networks"> <ul> <li><a href="https://www.linkedin.com/shareArticle?mini=true&url=https://ddblog.labcorp.com/2016/08/non-alcoholic-steatohepatitis/&title=The%20Development%20Landscape%20for%20Non-Alcoholic%20Steatohepatitis" rel="nofollow" target="_blank"><i class="fa fa-linkedin" aria-hidden="true"></i></a></li><li><a href="https://twitter.com/home?status=The%20Development%20Landscape%20for%20Non-Alcoholic%20Steatohepatitis https://ddblog.labcorp.com/2016/08/non-alcoholic-steatohepatitis/" rel="nofollow" target="_blank"><i class="fa fa-twitter" aria-hidden="true"></i></a></li><li><a href="https://www.facebook.com/sharer/sharer.php?u=https://ddblog.labcorp.com/2016/08/non-alcoholic-steatohepatitis/" rel="nofollow" target="_blank"><i class="fa fa-facebook" aria-hidden="true"></i></a></li><li><a href="/cdn-cgi/l/email-protection#526d012730383731266f063a37776062163724373e3d223f373c267760621e333c362131332237776062343d207760621c3d3c7f133e313d3a3d3e3b3177606201263733263d3a372233263b263b21747162616a69103d362b6f3a26262221687d7d3636303e3d357c3e3330313d20227c313d3f7d606263647d626a7d3c3d3c7f333e313d3a3d3e3b317f21263733263d3a372233263b263b217d" rel="nofollow" target="_blank"><i class="fa fa-envelope" aria-hidden="true"></i></a></li> </ul> </div> </div> </div><h2 class="entry-title" itemprop="headline"><a href="https://ddblog.labcorp.com/2016/08/non-alcoholic-steatohepatitis/" rel="bookmark">The Development Landscape for Non-Alcoholic Steatohepatitis</a></h2><div class="entry-meta"><span class="byline" itemprop="author" itemscope itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/covance/">Labcorp Drug Development</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2016/08/non-alcoholic-steatohepatitis/" rel="bookmark"><time class="entry-date published updated" datetime="2021-05-19T12:59:08-04:00" itemprop="dateModified">Wednesday, May 19, 2021</time><time class="updated" datetime="2016-08-03T08:54:47-04:00" itemprop="datePublished">Wednesday, August 3, 2016</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>The Development Landscape for Non-Alcoholic Steatohepatitis Q&A Q&A with Claudia Filozof, MD, PhD, Senior Medical Director in the Phase II-IV Cardiovascular/Metabolic Group and Richard Williams, PhD, JD, Executive Strategist, Global Regulatory Affairs Is this a good time to develop a NASH drug, and if so, why? Claudia: Yes, it’s a … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-2835 --> <article id="post-2676" class="post-2676 post type-post status-publish format-standard has-post-thumbnail hentry category-biomarkers category-clinical-development category-drug-development category-nash category-phase-iib-iii tag-biomarkers tag-nafld tag-nash latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2016/04/emerging-noninvasive-biomarkers-nash/" class="post-thumbnail"><img width="300" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-NASH-Liver-Disease-Blog-300x300-1.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="" srcset="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-NASH-Liver-Disease-Blog-300x300-1.jpg 300w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-NASH-Liver-Disease-Blog-300x300-1-150x150.jpg 150w" sizes="(max-width: 300px) 100vw, 300px" data-attachment-id="2705" data-permalink="https://ddblog.labcorp.com/2016/04/emerging-noninvasive-biomarkers-nash/rp_covance-nash-liver-disease-blog-300x300-jpg/" data-orig-file="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-NASH-Liver-Disease-Blog-300x300-1.jpg" data-orig-size="300,300" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="rp_Covance-NASH-Liver-Disease-Blog-300×300.jpg" data-image-description="" data-medium-file="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-NASH-Liver-Disease-Blog-300x300-1.jpg" data-large-file="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-NASH-Liver-Disease-Blog-300x300-1.jpg" /></a> <div class="text-holder"> <header class="entry-header"> <div class="top"> <div class="share"> <i class="fa fa-share-alt"></i>Share <div class="social-networks"> <ul> <li><a href="https://www.linkedin.com/shareArticle?mini=true&url=https://ddblog.labcorp.com/2016/04/emerging-noninvasive-biomarkers-nash/&title=What%20Are%20the%20Emerging%20Noninvasive%20Biomarkers%20in%20NASH?" rel="nofollow" target="_blank"><i class="fa fa-linkedin" aria-hidden="true"></i></a></li><li><a href="https://twitter.com/home?status=What%20Are%20the%20Emerging%20Noninvasive%20Biomarkers%20in%20NASH? https://ddblog.labcorp.com/2016/04/emerging-noninvasive-biomarkers-nash/" rel="nofollow" target="_blank"><i class="fa fa-twitter" aria-hidden="true"></i></a></li><li><a href="https://www.facebook.com/sharer/sharer.php?u=https://ddblog.labcorp.com/2016/04/emerging-noninvasive-biomarkers-nash/" rel="nofollow" target="_blank"><i class="fa fa-facebook" aria-hidden="true"></i></a></li><li><a href="/cdn-cgi/l/email-protection#9fa0cceafdf5fafceba2c8f7feebbaadafdeedfabaadafebf7fabaadafdaf2faedf8f6f1f8baadafd1f0f1f6f1e9feecf6e9fabaadafddf6f0f2feedf4faedecbaadaff6f1baadafd1deccd7a0b9bcafaca7a4ddf0fbe6a2f7ebebefeca5b0b0fbfbfdf3f0f8b1f3fefdfcf0edefb1fcf0f2b0adafaea9b0afabb0faf2faedf8f6f1f8b2f1f0f1f6f1e9feecf6e9fab2fdf6f0f2feedf4faedecb2f1feecf7b0" rel="nofollow" target="_blank"><i class="fa fa-envelope" aria-hidden="true"></i></a></li> </ul> </div> </div> </div><h2 class="entry-title" itemprop="headline"><a href="https://ddblog.labcorp.com/2016/04/emerging-noninvasive-biomarkers-nash/" rel="bookmark">What Are the Emerging Noninvasive Biomarkers in NASH?</a></h2><div class="entry-meta"><span class="byline" itemprop="author" itemscope itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/markparrish/">Mark Parrish, Associate Scientific Director, Biomarker Translation and Assay Development, Covance Genomics Laboratory</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2016/04/emerging-noninvasive-biomarkers-nash/" rel="bookmark"><time class="entry-date published updated" datetime="2021-07-26T16:36:46-04:00" itemprop="dateModified">Monday, July 26, 2021</time><time class="updated" datetime="2016-04-20T10:16:43-04:00" itemprop="datePublished">Wednesday, April 20, 2016</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>Novel biomarkers represent a promising means to improve diagnosis of nonalcoholic steatohepatitis (NASH). Currently, a definitive diagnosis requires a liver biopsy, a surgical procedure with many limitations. There are a variety of biomarkers that can assess liver status, but they do not always distinguish between patients with NASH and those … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-2676 --> <article id="post-2670" class="post-2670 post type-post status-publish format-standard has-post-thumbnail hentry category-clinical-development category-drug-development category-nash category-preclinical-nonclinical tag-nafld tag-nash tag-preclinical latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" class="post-thumbnail"><img width="450" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="Pre-Clinical Issues in NASH Development Covance Blog" srcset="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH.jpg 1500w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-300x200.jpg 300w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-768x512.jpg 768w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-1024x683.jpg 1024w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-450x300.jpg 450w" sizes="(max-width: 450px) 100vw, 450px" data-attachment-id="2672" data-permalink="https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/covance-pre-clinical-nash/" data-orig-file="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH.jpg" data-orig-size="1500,1000" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Covance Pre Clinical NASH" data-image-description="<p>Pre-Clinical Issues in NASH Development Covance Blog</p> " data-medium-file="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-300x200.jpg" data-large-file="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-1024x683.jpg" /></a> <div class="text-holder"> <header class="entry-header"> <div class="top"> <div class="share"> <i class="fa fa-share-alt"></i>Share <div class="social-networks"> <ul> <li><a href="https://www.linkedin.com/shareArticle?mini=true&url=https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/&title=How%20to%20Navigate%20Pre-Clinical%20Issues%20in%20NASH%20Development" rel="nofollow" target="_blank"><i class="fa fa-linkedin" aria-hidden="true"></i></a></li><li><a href="https://twitter.com/home?status=How%20to%20Navigate%20Pre-Clinical%20Issues%20in%20NASH%20Development https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" rel="nofollow" target="_blank"><i class="fa fa-twitter" aria-hidden="true"></i></a></li><li><a href="https://www.facebook.com/sharer/sharer.php?u=https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" rel="nofollow" target="_blank"><i class="fa fa-facebook" aria-hidden="true"></i></a></li><li><a href="/cdn-cgi/l/email-protection#211e7254434b4442551c694e56041311554e0413116f405748464055440413117153440c624d484f4842404d041311685252544452041311484f0413116f607269041311654457444d4e514c444f5507021112191a634e45581c49555551521b0e0e4545434d4e460f4d4043424e53510f424e4c0e131110170e11150e4f405748464055440c5153440c424d484f4842404d0c4852525444520c4f4052490c454457444d4e514c444f550e" rel="nofollow" target="_blank"><i class="fa fa-envelope" aria-hidden="true"></i></a></li> </ul> </div> </div> </div><h2 class="entry-title" itemprop="headline"><a href="https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" rel="bookmark">How to Navigate Pre-Clinical Issues in NASH Development</a></h2><div class="entry-meta"><span class="byline" itemprop="author" itemscope itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/gould/">Kenneth E. Gould, PhD and Subba Rao Chintalacharuvu, PhD</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" rel="bookmark"><time class="entry-date published updated" datetime="2021-05-19T12:45:27-04:00" itemprop="dateModified">Wednesday, May 19, 2021</time><time class="updated" datetime="2016-04-12T13:31:21-04:00" itemprop="datePublished">Tuesday, April 12, 2016</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>The pre-clinical phase of development for non-alcoholic steatohepatitis (NASH) drugs faces many challenges. Biopharmaceutical companies have several options for rodent models, but they must weigh factors such as customization versus speed before deciding on the best approach. Some of the challenges include: Diet: There is no prevailing wisdom in the … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-2670 --> </div> <div class="pagination"></div> </main><!-- #main --> </div><!-- #primary --> </div><!-- .row/not-found --> </div><!-- #content --> </div><!-- .container/.main-content --> <footer id="colophon" class="site-footer" itemscope itemtype="http://schema.org/WPFooter"> <div class="site-info"> <div class="container"> <span class="copyright">Copyright © 2022 Labcorp All rights reserved.</span> </div> </div> </footer><!-- #colophon --> <button aria-label="go to top" id="blossom-top"> <span><i class="fa fa-angle-up"></i>TOP</span> </button> </div><!-- #page --> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/all.min.js?ver=5.6.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/v4-shims.min.js?ver=5.6.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/sticky-kit.min.js?ver=1.1.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/owl.carousel.min.js?ver=2.2.1'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/owl.carousel.aria.min.js?ver=2.0.0'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/jquery.matchHeight.min.js?ver=0.7.2'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/wow.min.js?ver=1.1.3'></script> <script type='text/javascript'> /* <![CDATA[ */ var bfp_data = {"lightbox":"","auto":"","loop":"","speed":"3000","animation":"fadeOut","child":"default","sticky":"","sticky_widget":"","header":"eight","url":"https:\/\/ddblog.labcorp.com\/wp-admin\/admin-ajax.php","rtl":""}; /* ]]> */ </script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/custom.min.js?ver=2.3.3'></script> <script type='text/javascript'> /* <![CDATA[ */ var bfp_ajax = {"url":"https:\/\/ddblog.labcorp.com\/wp-admin\/admin-ajax.php","startPage":"1","maxPages":"1","nextLink":null,"autoLoad":"load_more","loadmore":"Load More Posts","loading":"Loading...","nomore":"No More Post","layouts":"two-col-right","plugin_url":"https:\/\/ddblog.labcorp.com\/wp-content\/plugins"}; /* ]]> */ </script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/ajax.min.js?ver=2.3.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-includes/js/wp-embed.min.js?ver=5.4'></script> <script type="text/javascript"> if(typeof _satellite !== "undefined"){ _satellite.pageBottom(); } </script> </body> </html>