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</ul> </div> </div> </div> </header> <div class="top-bar"> <div class="container"> <header class="page-header"> <h1 class="page-title">in vitro</h1> </header><!-- .page-header --> <div class="breadcrumb-wrapper"> <div id="crumbs" itemscope itemtype="http://schema.org/BreadcrumbList"> <span itemprop="itemListElement" itemscope itemtype="http://schema.org/ListItem"> <a itemprop="item" href="https://ddblog.labcorp.com"><span itemprop="name">Home</span></a> <meta itemprop="position" content="1" /> <span class="separator">/</span> </span><span class="current" itemprop="itemListElement" itemscope itemtype="http://schema.org/ListItem"><a itemprop="item" href="https://ddblog.labcorp.com/tag/in-vitro/"><span itemprop="name">in vitro</span></a><meta itemprop="position" content="2" /></span></div></div><!-- .breadcrumb-wrapper --> </div> </div> <div class="container main-content"> <div id="content" class="site-content"> <div class="row"> <div id="primary" class="content-area"> <main id="main" class="site-main"> <div class="row"> <article id="post-8568" class="post-8568 post type-post status-publish format-standard has-post-thumbnail hentry category-drug-development category-preclinical-nonclinical tag-genetic-toxicology tag-genetox tag-in-vitro tag-innovation tag-sparc latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2021/12/leading-the-way-in-new-study-options-rooted-in-the-3rs-with-genetic-toxicology-and-in-vitro-alternatives/" class="post-thumbnail"><img width="450" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2021/12/lab-450x300.png" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="Picture of Lab" srcset="https://ddblog.labcorp.com/wp-content/uploads/2021/12/lab-450x300.png 450w, https://ddblog.labcorp.com/wp-content/uploads/2021/12/lab-300x200.png 300w, https://ddblog.labcorp.com/wp-content/uploads/2021/12/lab-90x60.png 90w, 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aria-hidden="true"></i></a></li> </ul> </div> </div> </div><h2 class="entry-title" itemprop="headline"><a href="https://ddblog.labcorp.com/2021/12/leading-the-way-in-new-study-options-rooted-in-the-3rs-with-genetic-toxicology-and-in-vitro-alternatives/" rel="bookmark">Leading the way in new study options rooted in the 3Rs with genetic toxicology and in vitro alternatives</a></h2><div class="entry-meta"><span class="byline" itemprop="author" itemscope itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/covance/">Labcorp</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2021/12/leading-the-way-in-new-study-options-rooted-in-the-3rs-with-genetic-toxicology-and-in-vitro-alternatives/" rel="bookmark"><time class="entry-date published updated" datetime="2022-05-20T11:56:33-04:00" itemprop="dateModified">Friday, May 20, 2022</time><time class="updated" datetime="2021-12-08T10:53:14-05:00" itemprop="datePublished">Wednesday, December 8, 2021</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>30% More Genetic Toxicology Space Your continuing requirements to find new options for product testing inspired us to grow our capacity for genetic toxicology and in vitro alternatives. It’s an investment focused on enabling you to quickly and effectively respond to changing regulatory requirements as well as the evolving industry … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-8568 --> <article id="post-5462" class="post-5462 post type-post status-publish format-standard has-post-thumbnail hentry category-drug-development category-preclinical-nonclinical category-safety-assessment tag-immunology tag-immunotoxicology tag-in-vitro latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2019/10/5-different-kinds-of-cytokine-release-assays-weathering-the-storm-cra-post-ii/" class="post-thumbnail"><img width="450" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2019/10/data-image-samlois-1024x684.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="" 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href="/cdn-cgi/l/email-protection#bc83efc9ded6d9dfc88189998e8cd8d5dadad9ced9d2c8998e8cd7d5d2d8cf998e8cd3da998e8cdfc5c8d3d7d5d2d9998e8cced9d0d9ddcfd9998e8cddcfcfddc5cf86998e8ccbd9ddc8d4d9ced5d2db998e8cc8d4d9998e8ccfc8d3ced1998e8cc0998e8cffeefd998e8cecd3cfc8998e8cf5f59a9f8c8f8487fed3d8c581d4c8c8cccf869393d8d8ded0d3db92d0dddedfd3cecc92dfd3d1938e8c8d85938d8c938991d8d5dadad9ced9d2c891d7d5d2d8cf91d3da91dfc5c8d3d7d5d2d991ced9d0d9ddcfd991ddcfcfddc5cf91cbd9ddc8d4d9ced5d2db91c8d4d991cfc8d3ced191dfcedd91ccd3cfc891d5d593" rel="nofollow" target="_blank"><i class="fa fa-envelope" aria-hidden="true"></i></a></li> </ul> </div> </div> </div><h2 class="entry-title" itemprop="headline"><a href="https://ddblog.labcorp.com/2019/10/5-different-kinds-of-cytokine-release-assays-weathering-the-storm-cra-post-ii/" rel="bookmark">5 different kinds of cytokine release assays: weathering the storm | CRA Post II</a></h2><div class="entry-meta"><span class="byline" itemprop="author" itemscope itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/chriscooper/">Chris Cooper, Scientific Specialist II, Immunotoxicology & Immunology</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2019/10/5-different-kinds-of-cytokine-release-assays-weathering-the-storm-cra-post-ii/" rel="bookmark"><time class="entry-date published updated" datetime="2021-06-07T15:15:38-04:00" itemprop="dateModified">Monday, June 7, 2021</time><time class="updated" datetime="2019-10-15T12:40:50-04:00" itemprop="datePublished">Tuesday, October 15, 2019</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>In our previous post, we outlined the dangers of Cytokine Release Syndrome (CRS) and the importance of preclinical Cytokine Release Assays (CRAs) when developing monoclonal antibodies (mAbs) that interact with the patient’s immune system. In this second post, we describe the different kinds of assays in use and how these … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-5462 --> <article id="post-5457" class="post-5457 post type-post status-publish format-standard has-post-thumbnail hentry category-drug-development category-preclinical-nonclinical category-safety-assessment tag-immunology tag-immunotoxicology tag-in-vitro latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2019/10/in-vitro-cytokine-release-assays-is-there-calm-after-the-storm-cra-post-i/" class="post-thumbnail"><img width="450" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2019/10/Storm-1024x683-1.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="" srcset="https://ddblog.labcorp.com/wp-content/uploads/2019/10/Storm-1024x683-1.jpg 1024w, https://ddblog.labcorp.com/wp-content/uploads/2019/10/Storm-1024x683-1-300x200.jpg 300w, https://ddblog.labcorp.com/wp-content/uploads/2019/10/Storm-1024x683-1-768x512.jpg 768w, https://ddblog.labcorp.com/wp-content/uploads/2019/10/Storm-1024x683-1-450x300.jpg 450w" sizes="(max-width: 450px) 100vw, 450px" data-attachment-id="5459" data-permalink="https://ddblog.labcorp.com/2019/10/in-vitro-cytokine-release-assays-is-there-calm-after-the-storm-cra-post-i/rain-on-umbrella-2/" data-orig-file="https://ddblog.labcorp.com/wp-content/uploads/2019/10/Storm-1024x683-1.jpg" data-orig-size="1024,683" data-comments-opened="0" data-image-meta="{"aperture":"2.8","credit":"","camera":"Canon EOS 5DS R","caption":"Rain drops falling from a black umbrella concept for bad weather, winter or protection","created_timestamp":"1443525410","copyright":"","focal_length":"100","iso":"100","shutter_speed":"0.00625","title":"Rain on umbrella","orientation":"1"}" data-image-title="" data-image-description="" data-medium-file="https://ddblog.labcorp.com/wp-content/uploads/2019/10/Storm-1024x683-1-300x200.jpg" data-large-file="https://ddblog.labcorp.com/wp-content/uploads/2019/10/Storm-1024x683-1-1024x683.jpg" /></a> <div class="text-holder"> <header class="entry-header"> <div class="top"> <div class="share"> <i class="fa fa-share-alt"></i>Share <div class="social-networks"> <ul> <li><a href="https://www.linkedin.com/shareArticle?mini=true&url=https://ddblog.labcorp.com/2019/10/in-vitro-cytokine-release-assays-is-there-calm-after-the-storm-cra-post-i/&title=In%20vitro%20cytokine%20release%20assays:%20is%20there%20calm%20after%20the%20storm?%20|%20CRA%20Post%20I" rel="nofollow" target="_blank"><i class="fa fa-linkedin" aria-hidden="true"></i></a></li><li><a href="https://twitter.com/home?status=In%20vitro%20cytokine%20release%20assays:%20is%20there%20calm%20after%20the%20storm?%20|%20CRA%20Post%20I https://ddblog.labcorp.com/2019/10/in-vitro-cytokine-release-assays-is-there-calm-after-the-storm-cra-post-i/" rel="nofollow" target="_blank"><i class="fa fa-twitter" aria-hidden="true"></i></a></li><li><a href="https://www.facebook.com/sharer/sharer.php?u=https://ddblog.labcorp.com/2019/10/in-vitro-cytokine-release-assays-is-there-calm-after-the-storm-cra-post-i/" rel="nofollow" target="_blank"><i class="fa fa-facebook" aria-hidden="true"></i></a></li><li><a href="/cdn-cgi/l/email-protection#7d422e081f17181e09403413584f4d0b14090f12584f4d1e04091216141318584f4d0f1811181c0e18584f4d1c0e0e1c040e47584f4d140e584f4d0915180f18584f4d1e1c1110584f4d1c1b09180f584f4d091518584f4d0e09120f1042584f4d01584f4d3e2f3c584f4d2d120e09584f4d345b5e4d4e45463f121904401509090d0e47525219191f11121a53111c1f1e120f0d531e1210524f4d4c44524c4d521413500b14090f12501e04091216141318500f1811181c0e18501c0e0e1c040e50140e500915180f18501e1c1110501c1b09180f50091518500e09120f10501e0f1c500d120e09501452" rel="nofollow" target="_blank"><i class="fa fa-envelope" aria-hidden="true"></i></a></li> </ul> </div> </div> </div><h2 class="entry-title" itemprop="headline"><a href="https://ddblog.labcorp.com/2019/10/in-vitro-cytokine-release-assays-is-there-calm-after-the-storm-cra-post-i/" rel="bookmark">In vitro cytokine release assays: is there calm after the storm? | CRA Post I</a></h2><div class="entry-meta"><span class="byline" itemprop="author" itemscope itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/chriscooper/">Chris Cooper, Scientific Specialist II, Immunotoxicology & Immunology</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2019/10/in-vitro-cytokine-release-assays-is-there-calm-after-the-storm-cra-post-i/" rel="bookmark"><time class="entry-date published updated" datetime="2021-06-07T15:14:54-04:00" itemprop="dateModified">Monday, June 7, 2021</time><time class="updated" datetime="2019-10-15T12:33:34-04:00" itemprop="datePublished">Tuesday, October 15, 2019</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>What is a cytokine storm? Cytokine Release Syndrome (CRS), otherwise known as cytokine storm, is a systemic inflammatory response caused by complications due to disease, infection or an adverse effect of biologic therapy. The clinical symptoms of a cytokine storm are massive release of a potent cocktail of pro-inflammatory cytokines … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-5457 --> </div> <div class="pagination"></div> </main><!-- #main --> </div><!-- #primary --> </div><!-- .row/not-found --> </div><!-- #content --> </div><!-- .container/.main-content --> <footer id="colophon" class="site-footer" itemscope itemtype="http://schema.org/WPFooter"> <div class="site-info"> <div class="container"> <span class="copyright">Copyright © 2022 Labcorp All rights reserved.</span> </div> </div> </footer><!-- #colophon --> <button aria-label="go to top" id="blossom-top"> <span><i class="fa fa-angle-up"></i>TOP</span> </button> </div><!-- #page --> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/all.min.js?ver=5.6.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/v4-shims.min.js?ver=5.6.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/sticky-kit.min.js?ver=1.1.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/owl.carousel.min.js?ver=2.2.1'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/owl.carousel.aria.min.js?ver=2.0.0'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/jquery.matchHeight.min.js?ver=0.7.2'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/wow.min.js?ver=1.1.3'></script> <script type='text/javascript'> /* <![CDATA[ */ var bfp_data = {"lightbox":"","auto":"","loop":"","speed":"3000","animation":"fadeOut","child":"default","sticky":"","sticky_widget":"","header":"eight","url":"https:\/\/ddblog.labcorp.com\/wp-admin\/admin-ajax.php","rtl":""}; /* ]]> */ </script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/custom.min.js?ver=2.3.3'></script> <script type='text/javascript'> /* <![CDATA[ */ var bfp_ajax = {"url":"https:\/\/ddblog.labcorp.com\/wp-admin\/admin-ajax.php","startPage":"1","maxPages":"1","nextLink":null,"autoLoad":"load_more","loadmore":"Load More Posts","loading":"Loading...","nomore":"No More Post","layouts":"two-col-right","plugin_url":"https:\/\/ddblog.labcorp.com\/wp-content\/plugins"}; /* ]]> */ </script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/ajax.min.js?ver=2.3.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-includes/js/wp-embed.min.js?ver=5.4'></script> <script type="text/javascript"> if(typeof _satellite !== "undefined"){ _satellite.pageBottom(); } </script> </body> </html>