B-cell cloning, a recent improvement over typical hybridoma technology, is becoming an industry standard tool for the reliable and reproducible production of monoclonal antibodies. Read on to find out how we have successfully utilized B-cell cloning to produce antibody critical reagents, for a recombinant protein, and to learn how this …
Anti-Drug Antibody (ADA) Positive Controls Generation Against Oligonucleotide Therapeutics: Anti-Oligonucleotide Antibody Case Study
Oligonucleotide therapeutics are generally single-stranded synthetic oligonucleotides with modifications in their structure to improve stability and PK properties. These therapeutics generally target RNA transcripts and reduce or modify the corresponding protein expression. Unlike most typical biologic drug classes such as monoclonal antibodies, the oligonucleotides are relatively small in size and …
Antibody Critical Reagents: Challenges and Risks in Their Lifecycle Management
Antibody critical reagents are crucial to regulated (GxP) drug development assays. Poor quality reagents risk generating inaccurate and unreliable results, while failure in supply can delay preclinical and clinical studies. Overall, the potential consequences are losses in time, money and reputation. Read on to understand the key challenges in antibody …
Antibody reagents for your host cell protein assay: Experience counts
In the world of biopharmaceuticals and bioprocessing, ensuring the quality, safety, and efficacy of biotherapeutic products is of paramount importance. Host cell proteins (HCPs) are a critical component to consider in this context. HCPs are proteins of the host cells, typically microbial, insect or mammalian, used in the manufacturing of …