The EOGRTS or OECD 443 is a scientifically and logistically complex study. Five critical success factors can help you overcome the complexities to achieve DART success.
How to answer basic physical chemical questions for your chemical and agrochemical substances when test guidance changes and as regulatory standards evolve
Although most physiochemical endpoints are standard for crop and chemical active substances, selection of the right test method to assess them is critical. This blog reviews some standard endpoints and looks at the tests used, in the light of changing regulatory expectations and revised test methodologies for difficult substances.
DART: Secrets and advice on running successful studies
What is DART? DART stands for ‘developmental and reproductive toxicology’ and is the acronym commonly used in place of the term reproductive toxicology. DART studies assess a chemical’s effect on several aspects of reproductive capacity in laboratory animals. These include mating performance and fertility, sexual maturation, and offspring growth and …
K-REACH: how to register in 12 easy steps
In 2015, South Korea introduced legislation designed to protect human health and the environment from the impact of chemicals. With an estimated 44,000 chemicals in use in South Korea and about 300 new chemicals marketed annually, registrants and regulators will be kept busy assessing the risk posed to humans, animals …
How to run successful eFate studies for industrial chemicals
Environmental fate (eFate) studies are well established for crop protection chemicals and pharmaceuticals and are becoming commonplace for industrial chemicals, but what are the key considerations for setting up and running them?
New REACH nanomaterial requirements: what you need to do
The new EU nanotechnology regulation On December 3, 2018, the European Commission (EC) adopted Regulation 2018/1881, amending the existing , amending the existing Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation, to directly address nanoparticles. The nanotechnology regulation applies to any substance that might be, or might contain, a …
What you need to know about neonicotinoids and the EU
Introduction Neonicotinoids were developed to find safer, more effective alternatives to chlorinated hydrocarbons, organophosphates, carbamates, and pyrethroids, so, ironically, some neonicotinoids are now banned in the EU because of their toxicity to bees and other pollinators, as well as to a wider group of species. The agricultural and environmental consequences …
Understanding Annexes VII-X
Avoiding obstacles with REACH Annexes VII-X Posted by Dr. David Howes, Informed Consultant in Chemical Legislation and Chemistry. In the EU, the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulations address the manufacturing and import of chemicals to ensure they are safe for human health and the environment. The registration dossier …
Preserving lifecycles: renewing established pesticides
The regulation that governs the marketing, sale, and use of pesticides is just a fact of life, but the standards imposed are constantly evolving as our scientific insight and knowledge increases. This series of informational blogs is designed to examine how existing active substances (ASs) are managed through the current …