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</ul> </div> </div> </div> </header> <div class="top-bar"> <div class="container"> <header class="page-header"> <h1 class="page-title"><span class="vcard">Kenneth E. Gould, PhD and Subba Rao Chintalacharuvu, PhD</span></h1> </header><!-- .page-header --> <div class="breadcrumb-wrapper"> <div id="crumbs" itemscope itemtype="http://schema.org/BreadcrumbList"> <span itemprop="itemListElement" itemscope itemtype="http://schema.org/ListItem"> <a itemprop="item" href="https://ddblog.labcorp.com"><span itemprop="name">Home</span></a> <meta itemprop="position" content="1" /> <span class="separator">/</span> </span><span class="current" itemprop="itemListElement" itemscope itemtype="http://schema.org/ListItem"><a itemprop="item" href="https://ddblog.labcorp.com/author/gould/"><span itemprop="name">Kenneth E. Gould, PhD and Subba Rao Chintalacharuvu, PhD</span></a><meta itemprop="position" content="2" /></span></div></div><!-- .breadcrumb-wrapper --> </div> </div> <div class="container main-content"> <div id="content" class="site-content"> <div class="row"> <div id="primary" class="content-area"> <main id="main" class="site-main"> <div class="row"> <article id="post-2670" class="post-2670 post type-post status-publish format-standard has-post-thumbnail hentry category-clinical-development category-drug-development category-nash category-preclinical-nonclinical tag-nafld tag-nash tag-preclinical latest_post" itemscope itemtype="https://schema.org/Blog"> <a href="https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" class="post-thumbnail"><img width="450" height="300" src="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH.jpg" class="attachment-blossom-feminine-cat size-blossom-feminine-cat wp-post-image" alt="Pre-Clinical Issues in NASH Development Covance Blog" srcset="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH.jpg 1500w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-300x200.jpg 300w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-768x512.jpg 768w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-1024x683.jpg 1024w, https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-450x300.jpg 450w" sizes="(max-width: 450px) 100vw, 450px" data-attachment-id="2672" data-permalink="https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/covance-pre-clinical-nash/" data-orig-file="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH.jpg" data-orig-size="1500,1000" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Covance Pre Clinical NASH" data-image-description="<p>Pre-Clinical Issues in NASH Development Covance Blog</p> " data-medium-file="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-300x200.jpg" data-large-file="https://ddblog.labcorp.com/wp-content/uploads/2016/04/Covance-Pre-Clinical-NASH-1024x683.jpg" /></a> <div class="text-holder"> <header class="entry-header"> <div class="top"> <div class="share"> <i class="fa fa-share-alt"></i>Share <div class="social-networks"> <ul> <li><a href="https://www.linkedin.com/shareArticle?mini=true&url=https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/&title=How%20to%20Navigate%20Pre-Clinical%20Issues%20in%20NASH%20Development" rel="nofollow" target="_blank"><i class="fa fa-linkedin" aria-hidden="true"></i></a></li><li><a href="https://twitter.com/home?status=How%20to%20Navigate%20Pre-Clinical%20Issues%20in%20NASH%20Development https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" rel="nofollow" target="_blank"><i class="fa fa-twitter" aria-hidden="true"></i></a></li><li><a href="https://www.facebook.com/sharer/sharer.php?u=https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" rel="nofollow" target="_blank"><i class="fa fa-facebook" aria-hidden="true"></i></a></li><li><a href="/cdn-cgi/l/email-protection#ccf39fb9aea6a9afb8f184a3bbe9fefcb8a3e9fefc82adbaa5abadb8a9e9fefc9cbea9e18fa0a5a2a5afada0e9fefc85bfbfb9a9bfe9fefca5a2e9fefc828d9f84e9fefc88a9baa9a0a3bca1a9a2b8eaeffcfff4f78ea3a8b5f1a4b8b8bcbff6e3e3a8a8aea0a3abe2a0adaeafa3bebce2afa3a1e3fefcfdfae3fcf8e3a2adbaa5abadb8a9e1bcbea9e1afa0a5a2a5afada0e1a5bfbfb9a9bfe1a2adbfa4e1a8a9baa9a0a3bca1a9a2b8e3" rel="nofollow" target="_blank"><i class="fa fa-envelope" aria-hidden="true"></i></a></li> </ul> </div> </div> </div><h2 class="entry-title" itemprop="headline"><a href="https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" rel="bookmark">How to Navigate Pre-Clinical Issues in NASH Development</a></h2><div class="entry-meta"><span class="byline" itemprop="author" itemscope itemtype="https://schema.org/Person"> by <span class="author vcard" itemprop="name"><a class="url fn n" href="https://ddblog.labcorp.com/author/gould/">Kenneth E. Gould, PhD and Subba Rao Chintalacharuvu, PhD</a></span></span><span class="posted-on"><span class="text-on">updated on </span><a href="https://ddblog.labcorp.com/2016/04/navigate-pre-clinical-issues-nash-development/" rel="bookmark"><time class="entry-date published updated" datetime="2021-05-19T12:45:27-04:00" itemprop="dateModified">Wednesday, May 19, 2021</time><time class="updated" datetime="2016-04-12T13:31:21-04:00" itemprop="datePublished">Tuesday, April 12, 2016</time></a></span></div><!-- .entry-meta --> </header><!-- .entry-header home--> <div class="entry-content" itemprop="text"> <p>The pre-clinical phase of development for non-alcoholic steatohepatitis (NASH) drugs faces many challenges. Biopharmaceutical companies have several options for rodent models, but they must weigh factors such as customization versus speed before deciding on the best approach. Some of the challenges include: Diet: There is no prevailing wisdom in the … </p> </div><!-- .entry-content --> <footer class="entry-footer"> </footer><!-- .entry-footer home--> </div><!-- .text-holder --> </article><!-- #post-2670 --> </div> <div class="pagination"></div> </main><!-- #main --> </div><!-- #primary --> </div><!-- .row/not-found --> </div><!-- #content --> </div><!-- .container/.main-content --> <footer id="colophon" class="site-footer" itemscope itemtype="http://schema.org/WPFooter"> <div class="site-info"> <div class="container"> <span class="copyright">Copyright © 2021 Labcorp All rights reserved.</span> </div> </div> </footer><!-- #colophon --> <button aria-label="go to top" id="blossom-top"> <span><i class="fa fa-angle-up"></i>TOP</span> </button> </div><!-- #page --> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/all.min.js?ver=5.6.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/v4-shims.min.js?ver=5.6.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/sticky-kit.min.js?ver=1.1.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/owl.carousel.min.js?ver=2.2.1'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/owl.carousel.aria.min.js?ver=2.0.0'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/jquery.matchHeight.min.js?ver=0.7.2'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/wow.min.js?ver=1.1.3'></script> <script type='text/javascript'> /* <![CDATA[ */ var bfp_data = {"lightbox":"","auto":"","loop":"","speed":"3000","animation":"fadeOut","child":"default","sticky":"","sticky_widget":"","header":"eight","url":"https:\/\/ddblog.labcorp.com\/wp-admin\/admin-ajax.php","rtl":""}; /* ]]> */ </script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/custom.min.js?ver=2.3.3'></script> <script type='text/javascript'> /* <![CDATA[ */ var bfp_ajax = {"url":"https:\/\/ddblog.labcorp.com\/wp-admin\/admin-ajax.php","startPage":"1","maxPages":"1","nextLink":null,"autoLoad":"load_more","loadmore":"Load More Posts","loading":"Loading...","nomore":"No More Post","layouts":"two-col-right","plugin_url":"https:\/\/ddblog.labcorp.com\/wp-content\/plugins"}; /* ]]> */ </script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-content/themes/blossom-feminine-pro/js/ajax.min.js?ver=2.3.3'></script> <script type='text/javascript' src='https://ddblog.labcorp.com/wp-includes/js/wp-embed.min.js?ver=5.4'></script> <script type="text/javascript"> if(typeof _satellite !== "undefined"){ _satellite.pageBottom(); } </script> </body> </html>